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Colchicine

Colchicine

 

Colchicine

Colchicine is an alkaloid of Colchicum autumnale (autumn crocus, meadow saffron). It was isolated in 1820 by Pelletier and Caventou. Colchicum is also present in Gloriosa superba. Gloriosa superba which is also known as Flame lily is a tuberous herb, which is spread widely in tropical Asia, Southern Africa and Tropical regions. The medicinal value of Gloriosa superba lies in its abundantly available Colchicine that yields a stable physiological act on humans. It is a toxic natural product and secondary metabolite, originally extracted from plants of the genus Colchicum. Colchicine presents in the seeds of Gloriosa superba as well as in tuberous root of Gloriosa superba.

Green coffee beans are rich in several types of antioxidants including chlorogenic acids (caffeoylquinic acids and dicaffeoylquinic acids). Chlorogenic acids are cinnamic acid derivatives with biological effects mostly related to their antioxidant and anti-inflammatory activities. Chlorogenic acid is considered one of the most beneficial things about consuming coffee beans and the reason that green coffee supplements are said to act as natural weight loss aids and fat burners.

Identification

Cas No.: 64-86-8

Synonyms: Colchicina (Italian), Colchicin (German), Colchicum, Colchique (French), NSC 757

Structural formula
Colchicine
Colchicine
Pharmaceutical Features

Colchicine is used for the following therapeutic uses:

  • Remedial actions of sprains
  • Bruises
  • Colic
  • Hemorrhoids
  • Chronic ulcers
  • Nocturnal seminal emission
  • Leprosy and impotence
  • Gout
  • Mediterranean fever (FMF)